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We are investigating the genetic networks that regulate neural stem cell behaviour.

Neural stem cells in the adult brain exist primarily in a quiescent state but can be reactivated in response to changing physiological conditions.

How do stem cells sense and respond to metabolic changes?

To enable us to study the role of DNA-binding proteins in the developing nervous system, we developed ‘Targeted DamID’ (TaDa). TaDa permits genome-wide profiling of DNA- or chromatin-binding proteins in specific cells in vivo without cell sorting, fixation or affinity purification.

We have also developed RNA-DamID, a novel approach that detects lncRNA–genome interactions with high sensitivity and accuracy.