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It allows for temporal and spatial control of gene expression in vivo and has been adapted for many experimental uses. Click for more information and reagents. https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1521558404116-H4LPUQX26NBE2YUL0VR6/RNA+DamID.png Technologies Mapping long noncoding RNA-DNA interactions in vivo RNA DamID combines Targeted DamID with the MCP-MS2 system to profile long noncoding RNA (lncRNA) binding sites in the genome in specific cell types. Click for more information and reagents. https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1623162060847-LSBGVXX27R4S260E24O3/NanoDam-01.png Technologies - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1521558376556-PFH4CYDZC3114GJ8M5DB/Targeted+DamID.png Technologies Mapping protein-DNA interactions in vivo Targeted DamID (or “TaDa”) profiles genome-wide protein-DNA binding in vivo in a cell-type-specific way without cell purification. DNA adenine methyltransferase (Dam)-fusion proteins are expressed at very low levels with both spatial and temporal control. Click for more information and reagents. https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1549028465771-T4G4SL6ITAW07PYOP3F8/MaTaDa.png Technologies Mammalian Targeted DamID We have modified TaDa to generate mammalian TaDa (MaTaDa), which can be used to identify genome-wide protein/DNA interactions in 100 to 1000 times fewer cells than ChIP-based approaches. Click for more information and reagents. https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1528831593523-V539JRVGEPSV18W38D1T/Chromatin+DamID.png Technologies Determining chromatin states in specific cell types in vivo Chromatin TaDa uses Targeted DamID to assess the genome-wide occupancy of chromatin-binding proteins in vivo. Chromatin states can be determined by profiling RNA Pol II, Brm, HP1a, Pc and Histone H1 binding. Click for more information and reagents. https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1521558419107-L0QXCZOSEDFB33OOK2TF/Protocols+%26+Pipelines.png Technologies Tools for preparing Targeted DamID samples and data analysis Click for the latest molecular biology protocols and analysis pipelines for Targeted DamID. https://andreabrandlab.org/people daily 0.75 2025-12-16 https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1521577151272-JKLET68CJJZAM8IOI17W/Image4_People.jpg People https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1729110672440-9YTEMT9W5MHZ5H2U2XS8/Trip_to_Ellis_IslandAsset+2.png People https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1702841066586-ZYPC02SVKYWDN5X6UHES/CatherineParty.png People https://images.squarespace-cdn.com/content/v1/5a38fd84ccc5c519317b7464/1687388178047-9GNPANMMUB33T4NW0UHR/labretreat2022.png People 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